| 中文名称： |
福司氟康唑 |
| 英文名称: |
Fosfluconazole |
| 产品分类： |
小分子化合物(化合物库) |
| CAS号： |
194798-83-9 |
| 分子式： |
C13H13N6O4F2P |
| 分子量： |
386.25 |
*产品基础信息：
【产品中文名称】福司氟康唑;
【产品英文名称】Fosfluconazole;
【纯度指标】99.84%;
【品牌】TargetMol;
【CAS号】194798-83-9;
【浓度】;
Product Introduction
Bioactivity
| 名称 | Fosfluconazole |
| 描述 | Fosfluconazole is water-soluble phosphate prodrug of fluconazole. Fluconazole is an antifungal drug. |
| 激酶实验 | An aliquot of 200 μl of mucosa scrap lysate solution was mixed with 100 mM phosphate buffer, pH 7.4, to a final volume at 1 ml. The concentration of the test compounds (fosphenytoin and fosfluconazole) was 10 μM. The incubation medium was prewarmed at 37°C before the reaction was initiated by addition of the tested compounds. An aliquot of 100 μl was collected from the incubation vial at the time points 0, 5, 10, 20, 30, 45, and 60 min and transferred to a 96-well plate, in which 100 μl of acetonitrile was prefilled to terminate the reaction. The samples were diluted 5-fold with acetonitrile containing 1 μM tolbutamide as an analytical internal standard. The samples were centrifuged at 4000 rpm for 5 min to precipitate protein. The supernatant was transferred to a new 96-well plate for concentration analysis by liquid chromatography/tandem mass spectrometry (LC/MS/MS) [1]. |
| 动物实验 | Twelve-week-old male Wistar rats (200–300 g) were used. They were housed in a temperature-controlled room and were given food and water ad libitum. All rats were anesthetized by an i.p. administration of pentobarbital (50 mg/kg body weight). A catheter was placed in the peritoneal cavity and used as an inflow drain for the dialyzing fluid. sampling. In rats receiving i.v. administration, a catheter was inserted into the left jugular vein for drug administration, and another into the right femoral artery for blood sampling. Blood samples after the i.p. administration were obtained from the heart. The rats were then allowed to recover from the anesthesia and surgery for at least 24 hr. After the 40-mL dialyzing fluid was administered intraperitoneally, FLCZ 16 mg/kg body weight) and F-FLCZ (16 mg FLCZ eq/kg body weight) were administered intravenously. The volume of the drug solution administered intravenously was 8 mL/kg. FLCZ (16 mg/kg body weight) and F-FLCZ (16 mg FLCZ eq/kg body weight) dissolved in the 40 mL of dialyzing fluid were administered intraperitoneally. The dialyzing fluid FLCZ concentration was 100 mg/L. F-FLCZ (16 mg FLCZ eq/kg body weight) was administered to ARF rats intravenously and intraperitoneally. Blood (0.5 mL) and dialyzing ‰uid (1.5 mL) samples were collected at appropriate time intervals [2]. |
| 体外活性 | 在Caco-2单层细胞中，10 μM Fosfluconazole在Transwell板的顶端或底部隔室中给药。两种前药在顶端隔室中经过2小时孵化后被有效裂解。ALP介导的转化率随前药浓度呈依赖性，以Michaelis-Menten常数为标准，Fosfluconazole在Caco-2细胞中的测定值为351μM[1]。 |
| 体内活性 | Fosfluconazole通过静脉和腹膜内给药。在腹膜内给予F-FLCZ后，FLCZ在循环血液和腹膜透析大鼠的透析液中被检测到。腹膜内给药后血浆中FLCZ的浓度低于静脉给药(F-FLCZ)后的浓度[2]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 6 mg/mL (15.53 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.59 mM), Sonication is recommended.
|
| 关键字 | Inhibitor | inhibit | Fungal | Fosfluconazole | Antifungal |
| 相关产品 | D-Gluconic acid (solution) (50% in H2O) | Magnesium acetate tetrahydrate | Calcium Propionate | Benzyl propionate | Potassium gluconate | Dehydroacetic acid sodium | Terbinafine hydrochloride | Geraniol | Sulfacetamide sodium | L-Citronellol | Benzimidazole | Sodium formate |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Fungal Compound Library | Drug-induced Liver Injury (DILI) Compound Library | ReFRAME Related Library | Fluorochemical Library | FDA-Approved & Pharmacopeia Drug Library | Approved Drug Library | NO PAINS Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library |
*订购须知：
1.氚试特主营中高端生物试剂耗材，我们的经营理念是"把订试剂变得有意思！"。由于科研商品种类繁多，标定的商品图片仅作参考。工厂或因包材、批次变更等因素更换供货瓶子或其他包装，不影响产品品质，交货标准及瓶子包装以工厂当批次实际供货为准。如需售前确认，可与我们服务团队咨询，我们乐意为您提供优质的服务。
2.广东大部分高校可享受送货至实验室的服务。部分高校、企业可能受配送服务范围、门禁等因素影响，下单前可咨询我司线上服务团队，了解最新配送范围。氚试特/Trust将持续不断的扩充配送范围，为您提供优质的服务。
3.如因天气、大型促销活动等不可抗逆的因素影响，可能影响配送时间，我司配送员会及时与您联系协商配送时间。
4.科研试剂耗材大部分商品因运输等特殊性，非质量问题无法退换货。请下单前确认好产品参数，氚试特/Trust服务团队可提供专业的售前咨询服务。部分品牌非质量问退货换货可能需要您承担退货服务费，请务必确定好再下单。
5.我们深知科研领域对货物及时性的需求，并十分注重科学家的下单体验。一般视品牌每日发货截单时间不同到货时间可能有1天差异。大多品牌每日审批通过后下午15:30前可当日发货，部分品牌为17:00截单。氚试特/Trust每日接收到订单后会第一时间将订单及时送达到工厂仓库，一般当日晚上或次日上午9:30前更新运输单号，请您放心选购。如有十万火急的情况，请与我们服务团队协商。
6.自2025年1月1日起，我们联动科檬商城（科檬/ChemMole），开通订购积分功能。订单金额每满￥50=1积分。订单款项结算后，科檬系统会自动积分。锐竞平台订购的商品会自动同步积分。如您有积分的需求，请联系我们服务团队开通。
7.科檬积分致力于科学家们科研补贴补助，仅限用于科研或与科研建设相关用途，未经学校允许不得用于个人用途。
8.针对年订购量达10万以上或批量集采的课题组单位，可与我们开通VIP增值服务通道，我们将在打包选品及配送上为您提供个性化方案。
9.其他未尽事宜，欢迎随时与我们沟通。氚试特/Trust祝您在研途上一往无前，乘风破浪！
正品保障
授权代理 严苛选品
品种齐全
专业供应链 百万货源
合规保障
合规资质 售后无忧
