Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study carbapenem non-susceptible infections and Pseudomonas aeruginosa biofilm infections.
体内活性
In a neutropenic mouse model of biofilm lung infection, the pharmacokinetic parameters of Imipenem (MK0787) were assessed following a single intraperitoneal (IP) administration at various doses (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg). The killing effect was observed to be time-dependent[3].
存储条件
Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature.
溶解度
DMSO : 3 mg/mL (10.02 mM), Sonication is recommended.