氯氟醚菌唑

Mefentrifluconazole
氯氟醚菌唑
1417782-03-6
C18H15CLF3N3O2
397.78
品牌 商品编号 指标/纯度/参数 包装规格 目录价 您的价格 库存 数量 购物车
TargetMol TG-T11991-1mg 99.88% 1mg ¥833.00 登录可见优惠价格 In stock
TargetMol TG-T11991-2mg 99.88% 2mg ¥1220.00 登录可见优惠价格 现货
TargetMol TG-T11991-5mg 99.88% 5mg ¥1980.00 登录可见优惠价格 In stock
TargetMol TG-T11991-10mg 99.88% 10mg ¥3290.00 登录可见优惠价格 In stock
TargetMol TG-T11991-25mg 99.88% 25mg ¥5280.00 登录可见优惠价格 In stock
TargetMol TG-T11991-50mg 99.88% 50mg ¥7260.00 登录可见优惠价格 In stock
TargetMol TG-T11991-100mg 99.88% 100mg ¥9790.00 登录可见优惠价格 In stock
TargetMol TG-T11991-200mg 99.88% 200mg ¥13200.00 登录可见优惠价格 In stock
TargetMol TG-T11991-500mg 99.88% 500mg ¥19700.00 登录可见优惠价格 现货
TargetMol TG-T11991-1mL 99.88% 1mLx10mM(inDMSO) ¥1790.00 登录可见优惠价格 In stock
中文名称: 氯氟醚菌唑
英文名称: Mefentrifluconazole
产品分类: 小分子化合物(化合物库)
CAS号: 1417782-03-6
分子式: C18H15CLF3N3O2
分子量: 397.78
*产品基础信息:
【产品中文名称】氯氟醚菌唑;
【产品英文名称】Mefentrifluconazole;
【纯度指标】99.88%;
【品牌】TargetMol;
【CAS号】1417782-03-6;
【浓度】;


Product Introduction

Bioactivity

名称Mefentrifluconazole
描述Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent.
体内活性In the acute and repeat dose toxicity studies performed with Mefentrifluconazole.?A single-dose administration to rats the LD50 is >2000?mg/kg bwt by the oral route, >5000?mg/kg bwt by the dermal route, and >5.314?mg/L by inhalation as a dust aerosol.?Mefentrifluconazole is not a skin or an eye irritant, nor is it a phototoxicant in vitro.In the acute neurotoxicity study in rats, Mefentrifluconazole (oral administration;?2000?mg/kg bwt;?single dose) gives rise to reduce body weight gain and transient neurobehavioral effects only on the day of treatment (unsteady gait, reduced motor activity, reduces grip strength of the forelimbs and increased distance between the hind limbs in the landing foot-splay test).In the repeated-dose toxicity studies, the liver is the target organ in each of the three species investigated.?At higher dose levels in the rat (oral diets;?383/334 mg/kg/bwt/d (4000 ppm)) and the C57BL/6JRj mouse (61 mg/kg bwt/d (300 ppm)), reduces body weight gain and food consumption, alters clinical chemistry parameters, increases liver weight and is accompanied by liver cell hypertrophy, and/or liver cell necrosis.?At low doses, increases liver weight is not associated with any histopathological alterations and is considered to be an adaptive change to treatment.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度10% DMSO+90% Saline : 10 mg/mL (25.14 mM), Suspension.
DMSO : 250 mg/mL (628.49 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (12.57 mM), Sonication is recommended.
关键字necrosis | Mefentrifluconazole | liver | irritant | Inhibitor | inhibit | hypertrophy | Fungal | derivative | Cytochrome P450 | CYPs | CYP51A | cell | azole | aromatase | antifungal
相关产品D-Gluconic acid (solution) (50% in H2O) | Magnesium acetate tetrahydrate | Naringin | Calcium Propionate | Benzyl propionate | Ipriflavone | Potassium gluconate | Dehydroacetic acid sodium | Terbinafine hydrochloride | Geraniol | Sulfacetamide sodium | Sodium formate
相关库Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Fungal Compound Library | Metabolism Compound Library | Fluorochemical Library | Anti-Aging Compound Library | NO PAINS Compound Library | Antioxidant Compound Library | Orally Active Compound Library | Pesticide Compound Library





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