牛磺罗定

Taurolidine
都洛宁;滔罗林;牛磺罗定;1,1,1',1'-四氧化物;N-[3-(三乙氧基硅基)丙基]-2-甲酯基氮杂环丙烷;都洛宁,牛磺罗定;滔罗定;滔罗啶;4,4'-亚甲基双(四氢-1,2,4-磺胺嘧啶1,1-二氧化物);4,4'-亚甲双[四氢-2H-1,2,4-噻二嗪];4,4′-亚甲双[四氢-2H-1,2,4-噻二嗪]1,1,1′,1′-四氧化物;4,4′-亚甲基双(四氢-1,2,4-磺胺嘧啶 1,1-二氧化物);4,4'-亚甲双[四氢-2H-1,2,4-噻二嗪] 1,1,1',1'-四氧化物;牛磺罗定 50G
19388-87-5
C7H16N4O4S2
284.36
品牌 商品编号 指标/纯度/参数 包装规格 目录价 您的价格 库存 数量 购物车
TargetMol TG-T7533-25mg 99.81% 25mg ¥117.00 登录可见优惠价格 In stock
TargetMol TG-T7533-50mg 99.81% 50mg ¥163.00 登录可见优惠价格 In stock
TargetMol TG-T7533-100mg 99.81% 100mg ¥247.00 登录可见优惠价格 In stock
TargetMol TG-T7533-200mg 99.81% 200mg ¥363.00 登录可见优惠价格 In stock
TargetMol TG-T7533-500mg 0.9979 500mg ¥672.00 登录可见优惠价格 现货
TargetMol TG-T7533-1mL 99.79% 1mL*10mM(inDMSO) 1mL ¥99.00 登录可见优惠价格 现货
TargetMol TG-T7533-1g 0.9979 1g ¥993.00 登录可见优惠价格 现货
中文名称: 牛磺罗定
英文名称: Taurolidine
产品分类: 小分子化合物(化合物库)
CAS号: 19388-87-5
分子式: C7H16N4O4S2
分子量: 284.36
*产品基础信息:
【产品中文名称】牛磺罗定;
【产品英文名称】Taurolidine;
【纯度指标】99.81%;
【品牌】TargetMol;
【CAS号】19388-87-5;
【浓度】;


Product Introduction

Bioactivity

名称Taurolidine
描述Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
细胞实验In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
动物实验In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].
体外活性Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
体内活性In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
存储条件Keep away from direct sunlight,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.03 mM), Sonication is recommended.
DMSO : 50 mg/mL (175.83 mM), Sonication is recommended.
关键字venous | Taurolidine | Inhibitor | inhibit | infections | CVC | CRBSI | central | catheters | catheter-related | Bacterial | Apoptosis | antiseptic | antimicrobial | Antibiotic
相关产品Formamide | Guanidine hydrochloride | Aceglutamide | Neomycin sulfate | Terbinafine hydrochloride | Hemin | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate
相关库Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | NO PAINS Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Drug Library





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