| 中文名称： |
醋酸卡泊芬净 |
| 英文名称: |
Caspofungin Acetate |
| 产品分类： |
小分子化合物(化合物库) |
| CAS号： |
179463-17-3 |
| 分子式： |
C52H88N10O15.2[C2H4O2] |
| 分子量： |
1213.42 |
*产品基础信息：
【产品中文名称】醋酸卡泊芬净;
【产品英文名称】Caspofungin Acetate;
【纯度指标】99.82%;
【品牌】TargetMol;
【CAS号】179463-17-3;
【浓度】;
Product Introduction
Bioactivity
| 名称 | Caspofungin Acetate |
| 描述 | Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species. |
| 体外活性 | Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0) |
| 体内活性 | Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM cause no significant alterations in their ERG waveforms and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer[4]. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively[5]. |
| 存储条件 | Keep away from direct sunlight,Store at low temperature,Keep away from moisture,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 102 mg/mL (84.06 mM), Sonication is recommended.
H2O : 100 mg/mL (82.41 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (2.72 mM), Sonication is recommended.
|
| 关键字 | MK-0991 diacetate | MK-0991 | MK0991 | L-743873 | L743873 | L-743872 diacetate | L-743872 | L743872 | Inhibitor | inhibit | fungal cell wall | Fungal | Caspofungin diacetate | Caspofungin Acetate | antifungal | Antibiotic | 1,3-beta-D-glucan synthesis |
| 相关产品 | Calcium Propionate | Benzyl propionate | Levulinic acid | Doxycycline | Neomycin sulfate | Terbinafine hydrochloride | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Fungal Compound Library | Bioactive Compounds Library Max | Anti-Bacterial Compound Library | Cyclic Peptide Library | Antibiotics Library | EMA Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library |
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